The North Carolina Department of Health and Human Services is reporting the first case of monkeypox virus infection in a North Carolina resident, identified by testing at the State Laboratory of Public Health. Monkeypox is a rare but potentially serious, viral illness that typically involves flu-like symptoms, swelling of the lymph nodes and a rash that includes bumps that are initially filled with fluid before scabbing over. Illness could be confused with a sexually transmitted infection like syphilis or herpes, or with varicella zoster virus (chickenpox). Most infections last two to four weeks.