As COVID-19 cases and hospitalizations surge across North Carolina, the use of monoclonal antibodies for treatment of COVID-19 increased by 18-fold since late June from 100 administrations for the week of June 23 to 1,874 for the week of Aug. 11. Statewide, there are more than 130 sites offering monoclonal antibodies to treat COVID-19 as this treatment can decrease the likelihood of hospitalization related to COVID-19.